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Thursday, March 7 • 1:00pm - 3:00pm
New Regulatory Science in System Toxicology - Part II: Is an Update Needed, What Would Be the Critical Elements and By When? FULL

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New regulatory science in system toxicology: is an update needed, what would be the critical elements and by when?

Regulatory toxicology is used to control about $10 trillion (£6.2 trillion) worth of worldwide trade in chemicals, drugs, pesticides, food and consumer products.

While Europe has been pursuing change under the label of alternative methods and the 3Rs (reduce, replace, refine) for more than two decades, it was only a 2007 National Research Council report on the subject that prompted serious efforts to change the US system. The 3Rs approach had suggested either optimising animal tests (fewer animals or less pain and distress) or replacing traditional tests with in vitro or in silico models for harmonization.

The answer emerging in Europe is to combine various information sources in integrated (or intelligent) testing strategies (ITS). Despite the enormous possible impact this could have with EU legislations like REACH or the testing ban for cosmetic ingredients, efforts to further this are still limited. The answer emerging in the US is to adopt a new, molecular description of toxic action based on pathways of toxicity (PoT) – the biomolecular pathways that lead to a cell being harmed. This approach represents a paradigm shift in toxicity testing – identifying a substances effect on harmful cellular pathways, rather than interpreting effects on cell lines or entire organisms.

Synergies exist between these two approaches and two economic partners. Joint efforts to keep
leadership and achieve results are seek.



avatar for David Demortain

David Demortain

Political scientist with Sciences en Société (SenS)
David Demortain is a political scientist with the SENS (Sciences-en-Société) centre of the French Institut National de Recherche Agronomique (INRA), and a research associate of the Centre for Analysis of Risk and Regulation of the London School of Economics. His research and teaching activities cover risk regulation, with a particular focus on issues of scientific expertise for decision-making and risk assessment. He recently... Read More →

avatar for Bas Blaauboer

Bas Blaauboer

Doerenkamp-Zbinden Chair on Toxicology at IRAS-UU
Bas Blaauboer (1949) studied biology at Utrecht University and did a PhD in toxicology at the same university (1978). He spent a postdoctoral year at the MRC Toxicology Unit in the UK (1979), and when he returned to Utrecht led a group on in vitro toxicology (biochemical and cellular toxicology), first in the Department of Veterinary Pharmacology and Toxicology. Later the research in toxicology was moved to the interfacultary Research Institute... Read More →

Bob Diderich

Head of Division, Environment Directorate OECD, OECD
Bob Diderich has been involved in environmental hazard and risk assessment of chemical substances since 1992, when he joined the German Federal Environmental Agency. He was working in France between 1995 and 2002, first for the French Ministry of the Environment and then the French National Institute for Industrial Environment and Risks, where he was assessing the environmental risks of industrial chemicals and biocides. In 2002 he joined the... Read More →
avatar for Thomas Hartung

Thomas Hartung

CAAT US Director
Thomas Hartung, MD PhD, is professor and chair for toxicology, pharmacology, molecular microbiology, Evidence-based Toxicology and immunology at Johns Hopkins Bloomberg School of Public Health, Baltimore MD, and University of Konstanz, Germany. He directs the Centers of Alternative to Animal Testing (CAAT) of both universities. From 2002-2008 he led the European Center for the Validation of Alternative Methods (ECVAM) of the European Commission's... Read More →
avatar for Adriano Henney

Adriano Henney

Programme Director German Virtual Liver Network
Dr Henney obtained a PhD in Medicine and has 23 years’ research experience in cardiovascular disease in laboratories in London, Cambridge and Oxford. His interests have focused predominantly on atherosclerosis, with studies ranging from pathology, through molecular and cellular biology to molecular genetics. In 1997, he was recruited by Zeneca Pharmaceuticals from a Senior Fellowship position leading his own molecular genetics group in... Read More →
avatar for Bruno Hubesch

Bruno Hubesch

Dr Bruno Hubesch obtained his Master degree in Nuclear Chemistry in 1980 and his PhD in Physical Chemistry in the area of Photochemistry in 1985 from the University of Louvain, Belgium. During his PhD he carried out his research at the University of Strasbourg under supervision of Jean-Marie Lehn (Nobel Chemistry 1987). | After a year as non-commissioned officer in the Belgian Air Force, he pursued  from 1987 to 1990 postdoctoral research as... Read More →
avatar for Peter Lord

Peter Lord

Director, DiscoTox Ltd
I have spent a long career in cell and molecular toxicology, directing laboratories in the PreClinical Development Departments of several global Pharmaceutical Companies. I have championed the use of toxicogenomics in drug safety profiling and implemented cell and molecular biology approaches in investigative studies on a variety of drug toxicities. My main interests lie in establishing innovative methods in drug/chemical safety evaluation... Read More →

Vittorio Prodi, MEP

Chair of the Sky and Space Intergroup

Thursday March 7, 2013 1:00pm - 3:00pm
European Parliament A3H1

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